Human SOST/Sclerostin Protein (SOT-HM401)

  • Express System: HEK293
  • Product Tag: N-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: Immobilized Human SOST, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 6.3ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Gln24-Tyr213

Catalog: SOT-HM401

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Product Description Recombinant Human SOST/Sclerostin Protein is expressed from HEK293 with His and Avi tag at the N-Terminus.It contains Gln24-Tyr213.

Product Background

SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Product Category

Recombinant Protein

Target

SOST/Sclerostin
Synonyms sclerostin; SOST; VBCHsclerosteosis; CDD; DAND6; SOST1; VBCH

Gene/Protein ID

Q9BQB4-1

Species

Human

Exact Sequence

Gln24-Tyr213
Molecular Weight The protein has a predicted MW of 24.2 kDa. Due to glycosylation,the protein migrates to 28-40 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human SOST, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 6.3ng/ml determined by ELISA. See testing image for detail.

Product Tag

N-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human SOST, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 6.3ng/ml determined by ELISA.
Human SOST on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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