APC-equivalent Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein (MHC-HM10BTC)

  • Express System: HEK293
  • Product Tag: C-His
  • Activity: Immobilized APC-equivalent Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Antibody, hFc Tag with the EC50 of 4.3ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRHC peptide

Catalog: MHC-HM10BTC

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Product Description Recombinant APC-equivalent Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M) and HMTEVVRHC peptide.

Product Background

 p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.

Product Category

 Recombinant Protein

Target

 HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer
MHC Form Tetramer
Allele HLA-A*02:01

Gene/Protein ID

 A0A140T913(HLA-A*02:01)&P61769(B2M)&HMTEVVRHC

Species

 Human

Exact Sequence

 Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRHC peptide
Molecular Weight The protein has a predicted MW of 301.2 kDa.

Activity

 Immobilized APC-equivalent Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Antibody, hFc Tag with the EC50 of 4.3ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-His

Fluorophore

 APC

Express System

 HEK293
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS, 300mM NaCl (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized APC-equivalent Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Antibody, hFc Tag with the EC50 of 4.3ng/ml determined by ELISA.

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