Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) (IL8-CM1BPB)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
  • Biotinylated: yes
  • Activity: The affinity constant of 1.67 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Thr28-Pro207

Catalog: IL8-CM1BPB

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Product Description Recombinant Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the C-Terminus.It contains Thr28-Pro207.

Product Background

 Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.

Product Category

 Recombinant Protein

Target

 IL-18BP

Gene/Protein ID

 A0A2K5UDJ4

Species

 Cynomolgus

Exact Sequence

 Thr28-Pro207
Molecular Weight The protein has a predicted MW of 21.14 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.

Activity

 The affinity constant of 1.67 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated Cynomolgus IL-18BP, His tag captured on CM5 Chip via anti-his antibody can bind Human IL-18, No Tag with an affinity constant of 1.67 nM as determined in SPR assay (Biacore T200).
The purity of Biotinylated Cynomolgus IL-18BP is greater than 90% as determined by SEC-HPLC.
Biotinylated Cynomolgus IL-18BP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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