Biotinylated Human HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein (MHC-HM455B)
Catalog: MHC-HM455B
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| Product Description | Recombinant Biotinylated Human HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein is expressed from E.coli with with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVGADGVGK peptide. |
Product Background |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
Product Category |
Recombinant Protein |
Target |
HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer |
| MHC Form | Monomer |
| Allele | HLA-A*11:01 |
Gene/Protein ID |
AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVGADGVGK |
Species |
Human |
Exact Sequence |
Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVGADGVGK peptide |
| Molecular Weight | The protein has a predicted MW of 35.36 kDa (HLA-A*11:01) and 11.9 kDa (B2M) same as Tris-Bis PAGE result. |
Product Tag |
C-His-Avi |
Express System |
E.coli |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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The purity of Biotinylated HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer is greater than 95% as determined by SEC-HPLC. |
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Biotinylated HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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