Biotinylated Human CD96/TACTILE Protein (CD9-HM496B)
Catalog: CD9-HM496B
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| Product Description | Recombinant Biotinylated Human CD96/TACTILE Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Val22-Met503. |
Product Background |
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development. |
Product Category |
Recombinant Protein |
Target |
CD96/TACTILE |
Gene/Protein ID |
P40200-2 |
Species |
Human |
Exact Sequence |
Val22-Met503 |
| Molecular Weight | The protein has a predicted MW of 59.1 kDa. Due to glycosylation, the protein migrates to 115-140 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Anti-CD96 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human CD96, His Tag with the EC50 of 0.46ug/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Anti-CD96 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human CD96, His Tag with the EC50 of 0.46ug/ml determined by ELISA. |
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Biotinylated Human CD96 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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