Canine BMPR1A/ALK-3 Protein (ALK-DM201)
Catalog: ALK-DM201
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| Product Description | Recombinant Canine BMPR1A/ALK-3 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln24-Arg152. |
Product Background |
The type IA bone morphogenetic protein receptor (Bmpr1a), encoded by 11 exons and spanning about 40 kb on chromosome 14 in mice and chromosome 10 in human (Derynck & Feng, 1997; Mishina, Hanks, Miura, Tallquist, & Behringer, 2002), is an essential receptor for BMP signaling. |
Product Category |
Recombinant Protein |
Target |
BMPR1A |
Gene/Protein ID |
NP_001138622.1 |
Species |
Canine |
Exact Sequence |
Gln24-Arg152 |
| Molecular Weight | The protein has a predicted MW of 40.94 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-hFc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Measured by its ability to inhibit rhBMP4-induced alkaline phosphatase production by ATDC5 cells. The ED50-for this effect is typically 0.5 - 2.5 ug/mL in the presence of 50 ng/mL of recombinant human BMP4. |
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The purity of Canine BMPR1A is greater than 95% as determined by SEC-HPLC. |
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Canine BMPR1A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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