Biotinylated Human CCR6 Nanodisc (CCR-HM16NB)

Express System: HEK293
Product Tag: C-His
Activity: Immobilized Biotinylated Human CCR6 Nanodisc, His Tag at 5ug/ml (100ul/well)on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR6 Antibody, hFc Tag with the EC50 of 1.29ug/ml determined by ELISA. The affinity constant of 3.57 nM as determined in SPR assay (Biacore T200).
Recomended Products: Biotinylated Nanodisc Control (CON-HM1NB)
Amino Acid Range: Met1-Met374

Catalog #CCR-HM16NB

Price

$2,166.00

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Biotinylated Human CCR6 Nanodisc (CCR-HM16NB) Summary

Product Description	Recombinant Biotinylated Human CCR6 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Met374.
Product Background	The CC chemokine receptor 6 (CCR6), a G protein-coupled receptor (GPCR) is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation. Further, CCR6 mediates the homing of both CD4(+) T (T-helper; Th) cells and DCs to the gut mucosal lymphoid tissue.
Product Category	Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc

Protein	CCR6
Synonyms	C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; DRY6; DCR2; GPRCY4; LARC receptor; CD196; CKRL3, CMKBR6; GPR29; STRL22; BN-1
Accession	P51684
Species	Human
Biotinylated	yes
Amino Acid Range	Met1-Met374
Molecular Weight	The protein has a predicted MW of 55.4 kDa.
Activity	Immobilized Biotinylated Human CCR6 Nanodisc, His Tag at 5ug/ml (100ul/well)on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR6 Antibody, hFc Tag with the EC50 of 1.29ug/ml determined by ELISA. The affinity constant of 3.57 nM as determined in SPR assay (Biacore T200).
Product Tag	C-His
Fluorophore	Biotin-labeled
Expression System	HEK293
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Stability And Storage	Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Biotinylated Human CCR6 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-CCR6 Antibody, hFc Tag with an affinity constant of 3.57 nM as determined in SPR assay (Biacore T200).
	Immobilized Biotinylated Human CCR6 Nanodisc, His Tag at 5ug/ml (100ul/well)on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR6 Antibody, hFc Tag with the EC50 of 1.29ug/ml determined by ELISA.
	Loaded Biotinylated Human CCR6 Nanodisc, His Tag on Streptavidin-Biosensor can bind Anti-CCR6 Antibody, hFc Tag with an affinity constant of 2.28 nM as determined in BLI assay .

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