Chimeric HLA-A*02:01 (mα3) &mB2M&TERT (ILAKFLHWL) Monomer Protein (MHC-HM107)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Gly25-Thr206(Human HLA-A*02:01 α1&α2) & Asp207-Glu299(Mouse H-2Ld α3), Ile21-Met119(mB2M) and ILAKFLHWL peptide

Catalog: MHC-HM107

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Product Description Recombinant Chimeric HLA-A*02:01 (mα3) &mB2M&TERT (ILAKFLHWL) Monomer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr206 (Human HLA-A*02:01 α1&α2) and Asp207-Glu299 (Mouse H-2Ld α3), Ile21-Met119 (mB2M) and ILAKFLHWL peptide.

Product Background

 The human telomerase catalytic subunit human telomerase reverse transcriptase (hTERT) is expressed in many human cancer cells derived from multiple tissues, but infrequently in normal cells. Thus, hTERT is an attractive candidate target for tumor immunotherapy. hTERT:540–548 peptide (p540, ILAKFLHWL) has been identified as an effective HLA-A*0201-restricted T-cell epitope, an effective T-cell-based cancer treatment, including vaccines, against hTERT will likely require the identification of other MHC class I-restricted epitopes in this antigen.

Product Category

 Recombinant Protein

Target

 HLA-A*02:01 (mα3) &mB2M&TERT (ILAKFLHWL) Monomer
MHC Form Monomer
Allele HLA-A*02:01

Gene/Protein ID

 A0A140T913(Human HLA-A*02:01 α1&α2)&P01897(Mouse H-2Ld α3)&&P01887(Mouse B2M)&ILAKFLHWL

Species

 Human

Exact Sequence

 Gly25-Thr206(Human HLA-A*02:01 α1&α2) & Asp207-Glu299(Mouse H-2Ld α3), Ile21-Met119(mB2M) and ILAKFLHWL peptide
Molecular Weight The protein has a predicted MW of 48.00 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Chimeric HLA-A*02:01 (mα3) &mB2M&TERT (ILAKFLHWL) Monomer is greater than 95% as determined by SEC-HPLC.
Chimeric HLA-A*02:01 (mα3) &mB2M&TERT (ILAKFLHWL) Monomer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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