Cynomolgus 4-1BB Ligand/TNFSF9 Protein (BBL-CM241)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus/Rhesus macaque 4-1BB, His Tag at 0.2ug/ml (100ul/Well) on the plate. Dose response curve for Cynomolgus 4-1BB Ligand, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Arg68-Glu251

Catalog: BBL-CM241

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Product Description Recombinant Cynomolgus 4-1BB Ligand/TNFSF9 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Arg68-Glu251.

Product Background

 The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.

Product Category

 Recombinant Protein

Target

 4-1BB Ligand/TNFSF9
Synonyms 41BB Ligand; 4-1BB Ligand; 4-1BBL; CD137L; TNFSF9

Gene/Protein ID

 XP_015296398.1

Species

 Cynomolgus

Exact Sequence

 Arg68-Glu251
Molecular Weight The protein has a predicted MW of 46 kDa. Due to glycosylation, the protein migrates to 50-52 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Cynomolgus/Rhesus macaque 4-1BB, His Tag at 0.2ug/ml (100ul/Well) on the plate. Dose response curve for Cynomolgus 4-1BB Ligand, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-hFc

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Cynomolgus/Rhesus macaque 4-1BB, His Tag at 0.2ug/ml (100ul/Well) on the plate. Dose response curve for Cynomolgus 4-1BB Ligand, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA.
The purity of Cynomolgus 4-1BB Ligand is greater than 95% as determined by SEC-HPLC.
Cynomolgus 4-1BB Ligand on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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