Cynomolgus CCR8 Protein (CCR-CM308)

Express System: HEK293
Product Tag: C-mFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.27 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: Met1-Lys35

Catalog: CCR-CM308

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Product Description	Recombinant Cynomolgus CCR8 Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Met1-Lys35.
Product Background	CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection.
Product Category	Recombinant Protein

Target	CCR8
Gene/Protein ID	XP_015300839.1
Species	Cynomolgus
Exact Sequence	Met1-Lys35
Molecular Weight	The protein has a predicted MW of 29.73 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 0.27 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-mFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Anti-CCR8 Antibody, hFc Tag captured on CM5 Chip via Anti-Human Fc IgG Antibody can bind Cynomolgus CCR8, mFc Tag with an affinity constant of 0.27 uM as determined in SPR assay (Biacore T200).
	The purity of Cynomolgus CCR8 is greater than 95% as determined by SEC-HPLC.
	Cynomolgus CCR8 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.