Cynomolgus/Rhesus macaque CD19 Protein (CD1-CM119)
Catalog: CD1-CM119
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| Product Description | Recombinant Cynomolgus/Rhesus macaque CD19 Protein is expressed from HEK293 with His tag at the N-Terminus.; It contains Gln21 - Trp291. |
Product Background |
CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses.Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca2 stores. |
Product Category |
Recombinant Protein |
Target |
CD19 |
Gene/Protein ID |
A0A2K5W8L9 |
Species |
Cynomolgus/Rhesus macaque |
Exact Sequence |
Gln21 - Trp291 |
| Molecular Weight | The protein has a predicted MW of 30.96 kDa. Due to glycosylation, the protein migrates to 50 - 70 kDa based on Tris-Bis PAGE result. |
Activity |
The affinity constant of 0.48 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
N-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1 EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Anti-CD19 Antibody, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus/Rhesus macaque CD19, His Tag with an affinity constant of 0.48 uM as determined in SPR assay (Biacore T200). |
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Cynomolgus/Rhesus macaque CD19 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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