Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM127)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.5ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Gln23-Thr784

Catalog: CDH-CM127

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Product Description Recombinant Cynomolgus CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gln23-Thr784.

Product Background

 Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Product Category

 Recombinant Protein

Target

 CDH17/Cadherin 17

Gene/Protein ID

 XP_005563762.2

Species

 Cynomolgus

Exact Sequence

 Gln23-Thr784
Molecular Weight The protein has a predicted MW of 85.57 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Cynomolgus CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.5ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Cynomolgus CDH17, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 6.5ng/ml determined by ELISA.
The purity of Cynomolgus CDH17 is greater than 95% as determined by SEC-HPLC.
Cynomolgus CDH17 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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