Cynomolgus Coagulation factor XI Protein (FXI-CM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Cynomolgus Coagulation factor XI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Factor XI Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Glu44-Ala650

Catalog: FXI-CM101

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Product Description Recombinant Cynomolgus Coagulation factor XI Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu44-Ala650.

Product Background

 Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to FXIa by factor XIIa (FXIIa), a component, along with prekallikrein and high-molecular-weight kininogen (HK), of the plasma kallikrein-kinin system (KKS).

Product Category

 Recombinant Protein

Target

 Coagulation factor XI

Gene/Protein ID

 XP_005556540.2

Species

 Cynomolgus

Exact Sequence

 Glu44-Ala650
Molecular Weight The protein has a predicted MW of 69.05 kDa. Due to glycosylation, the protein migrates to 70-85 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Cynomolgus Coagulation factor XI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Factor XI Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Cynomolgus Coagulation factor XI, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Factor XI Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA.
The purity of Cynomolgus Coagulation factor XI Protein is greater than 95% as determined by SEC-HPLC.
Cynomolgus Coagulation factor XI on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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