Cynomolgus Fc gamma RIII/CD16 Protein (FGR-CM1R3)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.251 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Gly17-Gln208

Catalog: FGR-CM1R3

$240.00
Size:

Order now get it on

Bulk Quote | Test Sample
Product Description Recombinant Cynomolgus Fc gamma RIII/CD16 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly17-Gln208.

Product Background

 Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set.

Product Category

 Recombinant Protein

Target

 Fc gamma RIII/CD16
Synonyms IgG Fc receptor III; Fc-gamma RIII; FcRIII; FCGR3; CD16; CD16A; FCG3; FcgRIII; FCR-10; FCRIIIA; IGFR3; IMD20

Gene/Protein ID

 Q8SPW2-1

Species

 Cynomolgus

Exact Sequence

 Gly17-Gln208
Molecular Weight The protein has a predicted MW of 23.1 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Tris-Bis PAGE result.

Activity

 The affinity constant of 0.251 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Rituximab captured on CM5 Chip via Protein A can bind Cynomolgus Fc gamma RIII, His Tag with an affinity constant of 0.251 uM as determined in SPR assay (Biacore T200).
The purity of Cynomolgus Fc gamma RIII is greater than 95% as determined by SEC-HPLC.
Cynomolgus Fc gamma RIII on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

You may also be interested in

View more associated products