Cynomolgus IL-21R Protein (ILR-CM121)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IL-21 at 2ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus IL-21R, His Tag with the EC50 of 34.3ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Cys41-Gly254

Catalog: ILR-CM121

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Product Description	Recombinant Cynomolgus IL-21R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Cys41-Gly254.
Product Background	IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
Product Category	Recombinant Protein

Target	IL-21R
Gene/Protein ID	G7Q0S8
Species	Cynomolgus
Exact Sequence	Cys41-Gly254
Molecular Weight	The protein has a predicted MW of 25.70 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human IL-21 at 2ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus IL-21R, His Tag with the EC50 of 34.3ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human IL-21 at 2ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus IL-21R, His Tag with the EC50 of 34.3ng/ml determined by ELISA.
	The purity of Cynomolgus IL-21R is greater than 95% as determined by SEC-HPLC.
	Cynomolgus IL-21R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.