Cynomolgus LILRB1/CD85j/ILT2 Protein (LIL-CM1RB)
Catalog: LIL-CM1RB
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| Product Description | Recombinant Cynomolgus LILRB1/CD85j/ILT2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly41-His474. |
Product Background |
LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. |
Product Category |
Recombinant Protein |
Target |
LILRB1/CD85j/ILT2 |
Gene/Protein ID |
XP_045236898.1 |
Species |
Cynomolgus |
Exact Sequence |
Gly41-His474 |
| Molecular Weight | The protein has a predicted MW of 48.19 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Cynomolgus LILRB1, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-LILRB1 Antibody, hFc Tag with the EC50 of 29.6ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Cynomolgus LILRB1, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-LILRB1 Antibody, hFc Tag with the EC50 of 29.6ng/ml determined by ELISA. |
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The purity of Cynomolgus LILRB1 is greater than 95% as determined by SEC-HPLC. |
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Cynomolgus LILRB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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