Cynomolgus/Rhesus macaque TNFSF15 Protein (FSF-CM215)
Catalog: FSF-CM215
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| Product Description | Recombinant Cynomolgus/Rhesus macaque TNFSF15 Protein is expressed from HEK293 with monomeric Fc tag at the N-terminus.It contains Leu72-Leu251. |
Product Background |
TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. |
Product Category |
Recombinant Protein |
Target |
TNFSF15 |
Gene/Protein ID |
A0A2K5UA22 |
Species |
Cynomolgus/Rhesus macaque |
Exact Sequence |
Leu72-Leu251 |
| Molecular Weight | The protein has a predicted MW of 44.82 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Mouse DR3, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus/Rhesus macaque TNFSF15, hFc Tag with the EC50 of 17.5ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
N-monomeric Fc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Mouse DR3, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Cynomolgus/Rhesus macaque TNFSF15, hFc Tag with the EC50 of 17.5ng/ml determined by ELISA. |
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Immobilized Cynomolgus/Rhesus macaque TNFSF15, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-TNFSF15 Antibody, hFc Tag with the EC50 of 14.6ng/ml determined by ELISA. |
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The purity of Cynomolgus/Rhesus macaque TNFSF15 is greater than 90% as determined by SEC-HPLC. |
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Cynomolgus/Rhesus macaque TNFSF15 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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