Cynomolgus Siglec-10 Protein (SIG-CM110)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Activity: Immobilized Cynomolgus Siglec-10, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-Siglec-10 Antibody, hFc Tag with the EC50 of 17.7ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Thr17-Asn552

Catalog: SIG-CM110

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Product Description	Recombinant Cynomolgus Siglec-10 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr17-Asn552.
Product Background	Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.
Product Category	Recombinant Protein

Target	Siglec-10
Gene/Protein ID	A0A2K5WBX8
Species	Cynomolgus
Exact Sequence	Thr17-Asn552
Molecular Weight	The protein has a predicted MW of 59.90 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Cynomolgus Siglec-10, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-Siglec-10 Antibody, hFc Tag with the EC50 of 17.7ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22um filtered solution in 25mM MES, 150mM NaCl, 0.5M Arginine (pH 5.0).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus Siglec-10, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Anti-Siglec-10 Antibody, hFc Tag with the EC50 of 17.7ng/ml determined by ELISA.
	The purity of Cynomolgus Siglec-10 is greater than 90% as determined by SEC-HPLC.
	Cynomolgus Siglec-10 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.