Cynomolgus TYRO3 Protein (TYR-CM103)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by SEC-HPLC
  • Exact Sequence: Gly41-Ser427

Catalog: TYR-CM103

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Product Description Recombinant Cynomolgus TYRO3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly41-Ser427.

Product Background

 The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.

Product Category

 Recombinant Protein

Target

 TYRO3

Gene/Protein ID

 A0A2K5WCY8

Species

 Cynomolgus

Exact Sequence

 Gly41-Ser427
Molecular Weight The protein has a predicted MW of 42.47 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by SEC-HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Cynomolgus TYRO3 is greater than 95% as determined by SEC-HPLC.
Cynomolgus TYRO3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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