• Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GR-AMC). The specific activity is >8000 pmol/min/ยตg.
  • Amino Acid Range: Asp25-Leu463
Catalog #DPP-CM101
Price
Regular price $375.00
Regular price Sale price $375.00
/
Size
Avantor VWR Fisher Scientific

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Cynomolgus Cathepsin C/DPPI Protein (DPP-CM101) Summary

Product Description

 Recombinant Cynomolgus Cathepsin C/DPPI Protein is expressed from HEK293 with His tag at the C-terminus.It contains Asp25-Leu463.

Product Background

 Cathepsin C (CTSC) is a lysosomal cysteine protease constitutively expressed at high levels in the lung, kidney, liver, and spleen. It plays a key role in the activation of serine proteases in cytotoxic T cells, natural killer cells (granzymes A and B), mast cells (chymase and tryptase) and neutrophils (cathepsin G, neutrophil elastase, proteinase 3) underscoring its pivotal significance in immune and inflammatory defenses.

Product Category

 Recombinant Protein / Antibody discovery / Antibody discovery/Others

Cynomolgus Cathepsin C/DPPI Protein (DPP-CM101) Specifications/Details

Protein
 Cathepsin C/DPPI
Synonyms
 Cathepsin C; Cathepsin J; Dipeptidyl peptidase 1; CTSC; Dipeptidyl transferase
Accession
Species
 Cynomolgus
Biotinylated
 no
Amino Acid Range
 Asp25-Leu463
Molecular Weight
 The protein has a predicted MW of 51.1 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity
 Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GR-AMC). The specific activity is >8000 pmol/min/ยตg.
Product Tag
 C-His

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in 20mM MES, 150mM NaCl, 10% glycerol (pH 6.0).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80ยฐC.๏ผ› Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Cynomolgus Cathepsin C on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Cynomolgus Cathepsin C on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Cynomolgus Cathepsin C is greater than 95% as determined by SEC-HPLC. The purity of Cynomolgus Cathepsin C is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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