Human Activin RIIA/ACVR2A-Protein (ARA-HM22A)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIA, hFc Tag with the EC50 of 2.1ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Ala20-Pro135

Catalog: ARA-HM22A

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Product Description	Recombinant Human Activin RIIA/ACVR2A-Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ala20-Pro135.
Product Background	Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.
Product Category	Recombinant Protein

Target	Activin RIIA/ACVR2A
Gene/Protein ID	P27037-1
Species	Human
Exact Sequence	Ala20-Pro135
Molecular Weight	The protein has a predicted MW of W 39.35 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIA, hFc Tag with the EC50 of 2.1ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIA, hFc Tag with the EC50 of 2.1ng/ml determined by ELISA.
	The purity of Human Activin RIIA is greater than 95% as determined by SEC-HPLC.
	Human Activin RIIA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.