Human Activin RIIA/ACVR2A-Protein (ARA-HM32A)

Express System: HEK293
Product Tag: C-mFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIA, mFc Tag with the EC50 of 7.4ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Ala20-Pro135

Catalog: ARA-HM32A

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Product Description	Recombinant Human Activin RIIA/ACVR2A-Protein is expressed from HEK293 with mFc (IgG1) tag at the C-terminus.It contains Ala20-Pro135.
Product Background	Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.
Product Category	Recombinant Protein

Target	Activin RIIA/ACVR2A
Gene/Protein ID	P27037-1
Species	Human
Exact Sequence	Ala20-Pro135
Molecular Weight	The protein has a predicted MW of 39.07 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIA, mFc Tag with the EC50 of 7.4ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-mFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human Activin A, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human Activin RIIA, mFc Tag with the EC50 of 7.4ng/ml determined by ELISA.
	The purity of Human Activin RIIA is greater than 95% as determined by SEC-HPLC.
	Human Activin RIIA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.