Human CD93/C1q R1 Protein (CD9-HM193)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human CD93, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IGFBP-7, hFc Tag with the EC50 of 0.80ug/ml determined by ELISA. See testing image for detail.
Exact Sequence: Thr22-Lys580

Catalog: CD9-HM193

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Product Description	Recombinant Human CD93/C1q R1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr22-Lys580.
Product Background	CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperresponsiveness and inflammation with Th2 cytokine activation, along with decreased CD93 expression in bronchial epithelial cells and lung homogenates but increased serum CD93 levels.
Product Category	Recombinant Protein

Target	CD93/C1q R1
Synonyms	C1q/MBL/SPA receptor; C1qR; C1qR(p); C1qRp; CDw93; CD93; C1QR1; MXRA4; ECSM3; dJ737E23.1
Gene/Protein ID	Q9NPY3
Species	Human
Exact Sequence	Thr22-Lys580
Molecular Weight	The protein has a predicted MW of 59.4 kDa. Due to glycosylation, the protein migrates to 95-110 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human CD93, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IGFBP-7, hFc Tag with the EC50 of 0.80ug/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human CD93, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IGFBP-7, hFc Tag with the EC50 of 0.80ug/ml determined by ELISA.
	The purity of Human CD93 is greater than 95% as determined by SEC-HPLC.
	Human CD93 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.