Human CHRDL1 Protein (CDL-HE101)

Express System: E.coli
Product Tag: N-His
Purity: > 90% as determined by Tris-Bis PAGE
Activity: Immobilized Human CHRDL1, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CHRDL1 Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Glu28-Cys456

Catalog: CDL-HE101

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Product Description	Recombinant Human CHRDL1 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Glu28-Cys456.
Product Background	CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis.The hypermethylation of the CHRDL1 promoter in gastric cancer, which induced low expression of CHRDL1 and decreased its secretion to the supernatant.
Product Category	Recombinant Protein

Target	CHRDL1
Synonyms	Neuralin-1; Neurogenesin-1; Ventroptin; CHRDL1; NRLN1; CHL; Chordin-like 1; CRDL1; dA141H5.1; VOPT
Gene/Protein ID	Q9BU40-1
Species	Human
Exact Sequence	Glu28-Cys456
Molecular Weight	The protein has a predicted MW of 50 kDa same as Tris-Bis PAGE result.
Activity	Immobilized Human CHRDL1, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CHRDL1 Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA. See testing image for detail.
Product Tag	N-His
Express System	E.coli
Purity	> 90% as determined by Tris-Bis PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 4mM HCl. Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 4mM HCl.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human CHRDL1, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-CHRDL1 Antibody, hFc Tag with the EC50 of 9.4ng/ml determined by ELISA.
	Human CHRDL1 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.