Human Claudin 4 Protein-VLP (CLD-HM104)

  • Express System: HEK293
  • Purity: > 95% as determined by HPLC
  • Activity: Immobilized Human Claudin 4 VLP at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Met1-Val209

Catalog: CLD-HM104

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Product Description Recombinant Human Claudin 4 Protein-VLP is expressed from HEK293.It contains Met1-Val209.

Product Background

 Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

Product Category

 Recombinant Protein

Target

 Claudin 4

Gene/Protein ID

 O14493

Species

 Human

Exact Sequence

 Met1-Val209
Molecular Weight The target protein has a predicted MW of 23.31 kDa.

Activity

 Immobilized Human Claudin 4 VLP at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA. See testing image for detail.

Express System

 HEK293
Purity > 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Human Claudin 4 VLP at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA.
The purity of Human Claudin 4 VLP is greater than 95% as determined by SEC-HPLC.

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