Human Complement Component C1s Protein (C1S-HM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: Immobilized Human Complement Component C1S, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-C1S Antibody, hFc Tag with the EC50 of 9.6ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Glu16-Asp688

Catalog: C1S-HM101

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Product Description Recombinant Human Complement Component C1s Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu16-Asp688.

Product Background

 Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrome, and acute respiratory distress syndrome (ARDS).

Product Category

 Recombinant Protein

Target

 Complement Component C1s

Gene/Protein ID

 P09871

Species

 Human

Exact Sequence

 Glu16-Asp688
Molecular Weight The protein has a predicted MW of 75.98 kDa. Due to enzyme lysis glycosylation, the protein migrates to 55-60 kDa (light chain), 32-35 kDa (heavy chain) and 76-96 kDa based on Tris-Bis PAGE result.

Activity

 Immobilized Human Complement Component C1S, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-C1S Antibody, hFc Tag with the EC50 of 9.6ng/ml determined by ELISA. See testing image for detail.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Complement Component C1S, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-C1S Antibody, hFc Tag with the EC50 of 9.6ng/ml determined by ELISA.
Human Complement Component C1s on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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