Human DLL1/Delta1 Protein (DLL-HM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Gln18-Gly540

Catalog: DLL-HM101

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Product Description Recombinant Human DLL1/Delta1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln18-Gly540.

Product Background

 DLL1, a Notch signaling ligand, is significantly overexpressed in ERα luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor prognosis in ERα luminal breast cancer, but not in other subtypes of breast cancer. In addition, this effect is specific to DLL1, as other Notch ligands (DLL3, JAGGED1, and JAGGED2) do not influence the clinical outcome of ERα patients. DLL1-mediated Notch signaling in breast cancer is important for tumor cell proliferation, angiogenesis, and cancer stem cell function.

Product Category

 Recombinant Protein

Target

 DLL1/Delta1
Synonyms H-Delta-1; DLL1; DELTA1; DL1

Gene/Protein ID

 NP_005609

Species

 Human

Exact Sequence

 Gln18-Gly540
Molecular Weight The protein has a predicted MW of 57.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human DLL1 is greater than 95% as determined by SEC-HPLC.
Human DLL1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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