Human EREG Protein (ERE-HM201)

  • Express System: HEK293
  • Product Tag: N-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Val63-Leu108

Catalog: ERE-HM201

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Product Description Recombinant Human EREG Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Val63-Leu108.

Product Background

 Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.

Product Category

 Recombinant Protein

Target

 EREG
Synonyms Proepiregulin; EPR; Epiregulin; EREG; ER

Gene/Protein ID

 O14944

Species

 Human

Exact Sequence

 Val63-Leu108
Molecular Weight The protein has a predicted MW of 32.6 kDa. Due to glycosylation, the protein migrates to 37-42 kDa based on Tris-Bis PAGE result.

Product Tag

 N-hFc

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Human EREG is greater than 95% as determined by SEC-HPLC.
Human EREG on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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