Human GHR/Growth Hormone R Protein (GHR-HM101)
Catalog: GHR-HM101
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| Product Description | Recombinant Human GHR/Growth Hormone R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala27-Tyr264. |
Product Background |
Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual functions based on its localization in the plasma membrane and nucleus. |
Product Category |
Recombinant Protein |
Target |
GHR/Growth Hormone R |
| Synonyms | GH receptor; GHBP; GHR; GHR/BP |
Gene/Protein ID |
P10912-1 |
Species |
Human |
Exact Sequence |
Ala27-Tyr264 |
| Molecular Weight | The protein has a predicted MW of 28.8 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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The purity of Human GHR is greater than 95% as determined by SEC-HPLC. |
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Human GHR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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