Human GPRC5D Protein-VLP (GPR-HM05P)

Express System: HEK293
Purity: > 95% as determined by HPLC
Activity: Immobilized Human GPRC5D VLP at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 3.8ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: Met1-Val345

Catalog: GPR-HM05P

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Product Description	Recombinant Human GPRC5D Protein-VLP is expressed from HEK293.It contains Met1-Val345.
Product Background	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA.
Product Category	Recombinant Protein

Target	GPRC5D
Synonyms	GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
Gene/Protein ID	Q9NZD1-1
Species	Human
Exact Sequence	Met1-Val345
Molecular Weight	The target protein has a predicted MW of 39.6 kDa.
Activity	Immobilized Human GPRC5D VLP at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 3.8ng/ml determined by ELISA. See testing image for detail.
Express System	HEK293
Purity	> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22um filtered solution in PBS, 300mM L-Arginine (pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human GPRC5D VLP at 5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 3.8ng/ml determined by ELISA.
	The purity of Human GPRC5D VLP is greater than 95% as determined by SEC-HPLC.