Human IDH1 Protein (IDH-HE101)

  • Express System: E.coli
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
  • Exact Sequence: Ser2-Leu414

Catalog: IDH-HE101

$270.00
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Product Description Recombinant Human IDH1 Protein is expressed from E.coli with His tag at the C-Terminus.It contains Ser2-Leu414.

Product Background

 Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG). Genetic gain-of-function mutations in IDH1 and IDH2 confer a neomorphic activity that allow reduction of α -KG to (R)-2- hydroxyglutarate, the accumulation of which results in the development of cancers like low grade gliomas and leukemia.Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer.

Product Category

 Recombinant Protein

Target

 IDH1

Gene/Protein ID

 O75874

Species

 Human

Exact Sequence

 Ser2-Leu414
Molecular Weight The protein has a predicted MW of 47.35 kDa same as Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 E.coli
Purity > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in 50mM Tris, 200mM NaCl, 1mM DTT, 10% Glycerol (pH 7.5).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Human IDH1 is greater than 95% as determined by SEC-HPLC.
Human IDH1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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