Human IL-37 Protein (IL7-HE037)

Express System: E.coli
Product Tag: No Tag
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.12 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: Lys27-Asp192

Catalog: IL7-HE037

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Product Description	Recombinant Human IL-37 Protein is expressed from E.coli without tag.It contains Lys27-Asp192.
Product Background	IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes.
Product Category	Recombinant Protein

Target	IL-37
Gene/Protein ID	Q9NZH6-2
Species	Human
Exact Sequence	Lys27-Asp192
Molecular Weight	The protein has a predicted MW of 18.55 kDa same as Tris-Bis PAGE result.
Activity	The affinity constant of 0.12 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	No Tag
Express System	E.coli
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in 20mM PBS, 2mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Human IL-18BP, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-37, No Tag with an affinity constant of 0.12 uM as determined in SPR assay (Biacore T200).
	The purity of Human IL-37 is greater than 95% as determined by SEC-HPLC.
	Human IL-37 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.