Human IL-37b Protein (ILB-HE037)
Catalog: ILB-HE037
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| Product Description | Recombinant Human IL-37b Protein is expressed from E.coli without tag.It contains Val46~Asp218. |
Product Background |
IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune Interleukin-37 (IL-37), a newly described member of IL-1family, functioned as a fundamental inhibitor of innate inflammatory and immune responses. IL-37 has five different isoforms, and IL-37b is the most biologically functional subtype. IL-37b Inhibits PGN Induced Cytokines and Chemokines via the Downregulation of Intracellular Nuclear Factor (NF)-κB, PI3K–Akt, and ERK1/2 Pathways. |
Product Category |
Recombinant Protein |
Target |
IL-37b |
Gene/Protein ID |
Q9NZH6-1 |
Species |
Human |
Exact Sequence |
Val46~Asp218 |
| Molecular Weight | The protein has a predicted MW of 19.30 kDa same as Tris-Bis PAGE result. |
Product Tag |
No Tag |
Express System |
E.coli |
| Purity | > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in 20mM PB, 150mM NaCl, 2mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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The purity of Human IL-37b is greater than 90% as determined by SEC-HPLC. |
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Human IL-37b on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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