Human LGMN Protein (LGM-HM101)

  • Express System: HEK293
  • Product Tag: N-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Exact Sequence: Val18-Tyr433

Catalog: LGM-HM101

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Product Description Recombinant Human LGMN Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Val18-Tyr433.

Product Background

 Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.

Product Category

 Recombinant Protein

Target

 LGMN
Synonyms Legumain; Prsc1; AEP; LGMN; LGMN1; AI746452; AU022324

Gene/Protein ID

 Q99538-1

Species

 Human

Exact Sequence

 Val18-Tyr433
Molecular Weight The protein has a predicted MW of 48.6 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.

Product Tag

 N-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human LGMN on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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