Human MARCO Protein (MRO-HM102)
Catalog: MRO-HM102
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| Product Description | Recombinant Human MARCO Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Ser405-Val520. |
Product Background |
Macrophage receptor with collagenous structure (MARCO) is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). MARCO contributes to normal cholesterol uptake in macrophages; therefore, in the absence of MARCO, macrophages are more susceptible to a greater inflammatory response by particulates known to cause NLRP3 inflammasome activation and the effect is due to increased LMP. |
Product Category |
Recombinant Protein |
Target |
MARCO |
| Synonyms | MARCO; SCARA2; AI323439; Ly112 |
Gene/Protein ID |
Q9UEW3-1 |
Species |
Human |
Exact Sequence |
Ser405-Val520 |
| Molecular Weight | The protein has a predicted MW of 13.8 kDa. Due to glycosylation, the protein migrates to 14-20 kDa based on Tris-Bis PAGE result. |
Product Tag |
N-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS, 200mM L-arginine (pH 8.0). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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The purity of Human MARCO is greater than 95% as determined by SEC-HPLC. |
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Human MARCO on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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