Human SEZ6 Protein (SEZ-HM206)
Catalog: SEZ-HM206
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Product Description | Recombinant Human SEZ6 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu20-His925. |
Product Background |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. |
Product Category |
Recombinant Protein |
Target |
SEZ6 |
Gene/Protein ID |
Q53EL9-1 |
Species |
Human |
Exact Sequence |
Leu20-His925 |
Molecular Weight | The protein has a predicted MW of 124.53 kDa. Due to glycosylation, the protein migrates to 140-200 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Human SEZ6, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-SEZ6 Antibody, hFc Tag with the EC50 of 11.8ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Lyophilized |
Shipping | Shipped at ambient temperature. |
Formulation | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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