Human TFPI-2 Protein (TFP-HM102)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Exact Sequence: Asp23-Lys213.

Catalog: TFP-HM102

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Product Description Recombinant Human TFPI-2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp23-Lys213.

Product Background

 Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Moreover, in sputum from cystic fibrosis patients TFPI-2 C-terminal fragments are generated and found associated with immunoglobulins. Together our data describe a previously unknown host defense mechanism and therapeutic importance of TFPI-2 against invading Gram-negative bacterial pathogens.

Product Category

 Recombinant Protein

Target

 TFPI-2
Synonyms TFPI-2; PP5; TFPI2; REF1; TFPI-2REF1

Gene/Protein ID

 NP_006519.1

Species

 Human

Exact Sequence

 Asp23-Lys213.
Molecular Weight The protein has a predicted MW of 22.9 kDa. Due to glycosylation, the protein migrates to 30-35 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, the IC50 value is < 5 nM.
Human TFPI-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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