Human ULBP-4 Protein (ULB-HM204)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.17 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: His31-Asp225

Catalog: ULB-HM204

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Product Description	Recombinant Human ULBP-4 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains His31-Asp225.
Product Background	UL16-binding proteins (ULBPs) are markers of cellular stress which are upregulated on the surface of virus-infected and tumor cells. ULBPs are expressed by a variety of leukemias, carcinomas, melanomas, and tumor cell lines.ULBP4 is associated with higher levels of CD8+/NKG2D+ lymphocytes infiltrating the carcinoma and is a prognosticator of improved survival.
Product Category	Recombinant Protein

Target	ULBP-4
Gene/Protein ID	Q8TD07-1
Species	Human
Exact Sequence	His31-Asp225
Molecular Weight	The protein has a predicted MW of 49.12 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 0.17 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Human ULBP-4, hFc Tag captured on CM5 Chip via Protein A can bind Human NKG2D, His Tag with an affinity constant of 0.17 uM as determined in SPR assay (Biacore T200).
	The purity of Human ULBP-4 is greater than 95% as determined by SEC-HPLC.
	Human ULBP-4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.