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Human CD10/MME Protein (MME-HM110) Summary
Product Description |
Recombinant Human CD10/MME Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Tyr52-Trp750. |
Product Background |
CD10 is an endopeptidase that degrades various bioactive peptides in the extracellular matrix. In addition to enzymatic degradation, it affects multiple intracellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. CD10 expression pattern depended on the histotypes of thyroid lesions. When possible metastatic tumours and non-epithelial tumours are excluded, high CD10 expression may be useful in determining whether a primary thyroid carcinoma includes an anaplastic component. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human CD10/MME Protein (MME-HM110) Specifications/Details
Protein |
CD10/MME |
Synonyms |
Neprilysin; Atriopeptidase; Enkephalinase; NEP; Neutral; SFE; CD10; MME; CALLA; DKFZp686O16152; MGC126681; MGC126707 |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Tyr52-Trp750 |
Molecular Weight |
The protein has a predicted MW of 80.9 kDa. Due to glycosylation, the protein migrates to 81-110 kDa based on Bis-Tris PAGE result. |
Activity |
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp) -OH. The specific activity is > 1500 pmoles/min/ug. |
Product Tag |
N-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in 50mM MES, 100mM NaCl, 1mM ZnCl2, 10% Glycerol (pH 6.5). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
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Human CD10 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Human CD10 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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