Mouse GITR Ligand/TNFSF18 Protein (FSF-MM218)
Catalog: FSF-MM218
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| Product Description | Recombinant Mouse GITR Ligand/TNFSF18 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Thr47-Ser173. |
Product Background |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. |
Product Category |
Recombinant Protein |
Target |
GITR Ligand/TNFSF18 |
| Synonyms | TNFSF18; AITRL; TL6; GITRL; GITR Ligand |
Gene/Protein ID |
Q7TS55 |
Species |
Mouse |
Exact Sequence |
Thr47-Ser173 |
| Molecular Weight | The protein has a predicted MW of 41.8 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. |
Product Tag |
N-hFc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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The purity of Mouse GITR Ligand is greater than 95% as determined by SEC-HPLC. |
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Mouse GITR Ligand on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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