Mouse LGMN Protein (LGM-MM101)
Catalog: LGM-MM101
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Product Description | Recombinant Mouse LGMN Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Val18-Tyr435. |
Product Background |
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD. |
Product Category |
Recombinant Protein |
Target |
LGMN |
Synonyms | Legumain; Prsc1; AEP; LGMN; LGMN1; AI746452; AU022324 |
Gene/Protein ID |
O89017 |
Species |
Mouse |
Exact Sequence |
Val18-Tyr435 |
Molecular Weight | The protein has a predicted MW of 48.6 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Tris-Bis PAGE result. |
Product Tag |
N-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Liquid |
Shipping | Shipped with dry ice. |
Formulation | Supplied as 0.22um filtered solution in PBS (pH 7.4). |
Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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