Mouse MUC18/CD146 Protein (MUC-MM118)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Val24-Val563

Catalog: MUC-MM118

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Product Description Recombinant Mouse MUC18/CD146 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val24-Val563.

Product Background

 METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells.

Product Category

 Recombinant Protein

Target

 MUC18/CD146
Synonyms Gicerin; CD146; MCAM; MUC18

Gene/Protein ID

 Q8R2Y2-1

Species

 Mouse

Exact Sequence

 Val24-Val563
Molecular Weight The protein has a predicted MW of 60.9 kDa. Due to glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Mouse MUC18 is greater than 95% as determined by SEC-HPLC.
Mouse MUC18 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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