Mouse TMEM106B Protein (TEM-MM26B)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Pro119-Gln275

Catalog: TEM-MM26B

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Product Description Recombinant Mouse TMEM106B Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Pro119-Gln275.

Product Background

 TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).

Product Category

 Recombinant Protein

Target

 TMEM106B
Synonyms Transmembrane protein 106B；Tmem106b

Gene/Protein ID

 Q80X71

Species

 Mouse

Exact Sequence

 Pro119-Gln275
Molecular Weight The protein has a predicted MW of 44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Tris-Bis PAGE result.

Product Tag

 C-hFc

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Mouse TMEM106B is greater than 95% as determined by SEC-HPLC.
Mouse TMEM106B on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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