Mouse TYRO3 Protein (TYR-MM103)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Arg31-Asp419

Catalog: TYR-MM103

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Product Description Recombinant Mouse TYRO3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Arg31-Asp419.

Product Background

 The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.

Product Category

 Recombinant Protein

Target

 TYRO3
Synonyms BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse

Gene/Protein ID

 P55144-2

Species

 Mouse

Exact Sequence

 Arg31-Asp419
Molecular Weight The protein has a predicted MW of 43 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on Tris-Bis PAGE result.

Product Tag

 C-His

Express System

 HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Mouse TYRO3 is greater than 95% as determined by SEC-HPLC.
Mouse TYRO3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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