Name: Human PRNP Protein (PRP-HM201)
Brand: KactusBio
SKU: PRP-HM201-100UG
Price: 297.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc (IgG1)
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Human PRNP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-PRNP Antibody, hFc Tag with the EC50 of 41.7ng/ml determined by ELISA.
Amino Acid Range: Lys23-Ser230

Catalog #PRP-HM201

Size

100UG

500UG

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Human PRNP Protein (PRP-HM201) Summary

Product Description	Recombinant Human PRNP Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Lys23-Ser230.
Product Background	Prion protein gene (PRNP) variants determine the susceptibility of humans, sheep and mice to prion diseases, whereas polymorphisms in the open reading frame (ORF) of bovine PRNP seem to be unrelated to the incidence of bovine spongiform encephalopathy (BSE). According to the latest reports, the genetic susceptibility of cattle to BSE is associated with polymorphisms ofthe regulatory region of the PRNP gene and the level ofits expression.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Human PRNP Protein (PRP-HM201) Specifications/Details

Protein	PRNP
Synonyms	Major prion protein;PrP;ALTPRP;PRIP;PRP;PRNP
Accession	P04156
Species	Human
Biotinylated	no
Amino Acid Range	Lys23-Ser230
Molecular Weight	The protein has a predicted MW of 49.4 kDa. Due to glycosylation, the protein migrates to 60-67 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Human PRNP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-PRNP Antibody, hFc Tag with the EC50 of 41.7ng/ml determined by ELISA.
Product Tag	C-hFc (IgG1)
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Human PRNP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-PRNP Antibody, hFc Tag with the EC50 of 41.7ng/ml determined by ELISA.
	Human PRNP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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