Rat IL-22R alpha 1 Protein (ILR-RM122)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.145 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: His16-Ala228

Catalog: ILR-RM122

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Product Description	Recombinant Rat IL-22R alpha 1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains His16-Ala228.
Product Background	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3.
Product Category	Recombinant Protein

Target	IL-22R alpha 1
Gene/Protein ID	NP_001178798.1
Species	Rat
Exact Sequence	His16-Ala228
Molecular Weight	The protein has a predicted MW of 25.42 kDa. Due to glycosylation, the protein migrates to 37-45 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 0.145 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Rat IL-22R alpha 1, His Tag immobilized on CM5 Chip can bind Biotinylated Mouse IL-22, His Tag with an affinity constant of 0.145 uM as determined in SPR assay (Biacore T200).
	The purity of Rat IL-22R alpha 1 is greater than 95% as determined by SEC-HPLC.
	Rat IL-22R alpha 1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.