Rat IL-22R alpha 1 Protein (ILR-RM222)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Human IL-22, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Rat IL-22R alpha 1, hFc Tag with the EC50 of 30.4ng/ml determined by ELISA. See testing image for detail.
Exact Sequence: His16-Ala228

Catalog: ILR-RM222

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Product Description	Recombinant Rat IL-22R alpha 1 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains His16-Ala228.
Product Background	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3.
Product Category	Recombinant Protein

Target	IL-22R alpha 1
Gene/Protein ID	NP_001178798.1
Species	Rat
Exact Sequence	His16-Ala228
Molecular Weight	The protein has a predicted MW of 51.08 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Human IL-22, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Rat IL-22R alpha 1, hFc Tag with the EC50 of 30.4ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS, 100m L-Arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Human IL-22, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Rat IL-22R alpha 1, hFc Tag with the EC50 of 30.4ng/ml determined by ELISA.
	The purity of Rat IL-22R alpha 1 is greater than 95% as determined by SEC-HPLC.
	Rat IL-22R alpha 1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.