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Mouse SEMA4B Protein (SEM-MM14B) Summary
Product Description |
Recombinant Mouse SEMA4B Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu31-Glu703. |
Product Background |
Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Mouse SEMA4B Protein (SEM-MM14B) Specifications/Details
Protein |
SEMA4B |
Synonyms |
Semaphorin-4B; Semaphorin-C; SEMA4B; KIAA1745; SEMAC; MGC131831; SemC |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Leu31-Glu703 |
Molecular Weight |
The protein has a predicted MW of 75.7 kDa. Due to glycosylation, the protein migrates to 78-83 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Mouse SEMA4B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Mouse SEMA4B is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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