Human TYRO3 Protein (TYR-HM103) Summary
Product Description |
Recombinant Human TYRO3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala41-Trp429. |
Product Background |
The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Human TYRO3 Protein (TYR-HM103) Specifications/Details
Protein |
TYRO3 |
Synonyms |
BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse |
Accession |
|
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Ala41-Trp429 |
Molecular Weight |
The protein has a predicted MW of 42.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 2.36 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Human GAS6, His Tag immobilized on CM5 Chip can bind Human TYRO3, His Tag with an affinity constant of 2.36 uM as determined in SPR assay (Biacore T200). |
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Human TYRO3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Human TYRO3 is greater than 95% as determined by SEC-HPLC. |
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