APC-equivalent Human HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein (MHC-HM10CTC)
Catalog: MHC-HM10CTC
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| Product Description | Recombinant APC-equivalent Human HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr305 (HLA-C 03:04), Ile21-Met119 (B2M) and GADGVGKSAL peptide. |
Product Background |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
Product Category |
Recombinant Protein |
Target |
HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer |
| MHC Form | Tetramer |
| Allele | HLA-C 03:04 |
Gene/Protein ID |
QAV56463.1(HLA-C*03:04)&P61769(B2M)&GADGVGKSAL |
Species |
Human |
Exact Sequence |
Gly25-Thr305(HLA-C 03:04), Ile21-Met119(B2M) and GADGVGKSAL peptide |
| Molecular Weight | The protein has a predicted MW of 300.4 kDa. |
Product Tag |
C-His |
Fluorophore |
APC |
Express System |
HEK293 |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Liquid |
| Shipping | Shipped with dry ice. |
| Formulation | Supplied as 0.22 um filtered solution in PBS, 300mM NaCl (pH 7.4). |
| Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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